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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 4 Documents
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Search results for , issue "Vol. 9, No. 2" : 4 Documents clear
Uji Stabilitas Fisik dan Aktivitas Antioksidan Formula Krim yang Mengandung Ekstrak Kulit Buah Delima Djajadisastra, Joshita; Amin, Juheini
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Delima (Punica granatum L) merupakan salah satu buah memiliki aktivitas antioksidan yang kuat karena mengandung senyawa flavanoid dan tannin seperti asam elagic, asam gallat, punicalin, punicalagin, anthocianin, elligatanin, gallotanin, kuersetin, katekin. Senyawa—senyawa ini diketahui dapat mencegah dan menghambat terbentuknya radikal bebas yang penyebabkan penuaan dini dan penyakit kronis. Dalam penelitian ini ekstrak kulit buah delima diformulasikan dalam bentuk krim yang dibedakan kandungan nya yaitu konsentrasi 0, 75%, 1%, 2%. Uji kestabilan fisik dilakukan dengan penyimpanan sediaan pada tiga suhu yaitu suhu kamar; suhu 40C; 40,2 C, uji mekanik dan cycling test. Hasil penelitian ini menunjukkkan bahwa krim ekstrak kulit buah delima 0,75%,1% dan 2% memiliki kestabilan setelah pengujian suhu kamar; suhu 40C; 40,2 C, uji mekanik dan cycling test. Penentuan aktivitas antioksidan dilakukan dengan metode peredaman DPPH berdasarkan nilai penghambatan (IC50) yang didapat. Dengan demikian diperoleh hasil bahwa krim ekstrak kulit buah delima dengan konsentrasi 0, 75%, 1 % dan 2% memiliki aktivitas antioksidan dan masih memenuhi nilai minimum IC50. Uji statistik Anova menunjukkan bahwa aktivitas antioksidan pada krim ekstrak kulit buah delima dengan waktu peyimpanan to sampai t8 mengalami penurunan yang tidak bermakna dan penurunan aktivitas antioksidan sebelum dan sesudah penyinaran UV A dengan uji Wilcoxon pada krim ekstrak kulit buah delima juga tidak bermakna
Uji Efek Analgesik Ekstrak Etanol Mencit Jantan dengan Metode Tail-Flick Widiarti, Widiarti; Andrajati, Retnosari; Amin, Juheini
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

In the previous study the analgesic effect of Cinnamommum zeylanicum Breyn had been investigating. The aim of this study was to investigate analgesic effect of the 70% ethanol extract of cinnamon bark (Cinnamommum zeylanicum Breyn.). This study used Tail Flick method at 25 male mice which have passed sensitivity test, divided into five groupes. Group I as negative control was administered 0,5% CMC, group Il as positive control was administered tramadol HCI, group Ill, IV and V was administered extract of cinnamon bark at 8; 16 and 32 mg/20 g BW. Drugs were orally administered to mice. The reaction of time exhibited by each animal was counted for two hour with interval thirty minutes. The Result revealed that the prepared extract in at the all dose, had analgesic effect significantly in all groups which have been studied (p< 0,05) in comparison to the negative control, to the highest analgesic effect by dose (32 mg/ 20 g BW). Our results showed that the analgesic effect of extract (32 mg/20 g BW) the same with tramadol hidroclorida.
Analisis Zat Warna Merah Sintetik pada Selai Stroberi yang Dijual di Pasar Tradisional Kota Depok Ayuningtyas, Putri; Sauriasari, Rani; Kurniadi, Maryati
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Jam is a semi-solid food products made of fruit cooked with sugar that used as aflavoring on bakery including strawberry jam. Strawberry jam is added to food additives such as food dyes. The purpose of this study is to know about ponceau 4R, allura red, rodamin B, and amaran in the sample of strawberry jam in the traditional market at Depok City and to determine the levels of synthetic red dyes that are permitted on the sample strawberry jam. The method applied was dye isolation with wool and followed by analysis using a color reaction, then followed by paper chromatography using mobile phase n-butanol-eth-anol-water (3:4:4) and isobutanol-ethanol-water (3:2:4 ) and also TLC Densitometri using eluent ethanol-n-butanol-water (3:7:1). The result of study that from eight that has been investigated, it was found that six of them was contained ponceau 4R with levels of each sample at 0, 01164; 0, 00469; 0, 00974; 0, 00283; 0, 00482 and 0, 00435% still safe to consume.
Discovery of SARS-CoV-2 RNA-dependent-RNA-polymerase (RdRp) Inhibitor from Sambiloto (Andrographis paniculata) Based on Molecular Docking and ADMET Prediction Approach Ahsana, Dina; Pratama, Rizki Rahmadi; Meily, Alfisyahriatunnida; Andika, Andika
Pharmaceutical Sciences and Research Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

The rapid spread of the coronavirus disease 2019 (COVID-19) has led to the development of therapeutic inhibitor drug of SARS-CoV-2, which can inhibit the viral enzyme RNA-dependent-RNA-polymerase (RdRp), thereby preventing the replication, transcription, and synthesis of RNA virus in the host cells. Previous in-vitro studies revealed that Andrographis paniculata has the potential to inhibit the virus. Therefore, this study aims to isolate the specific compounds of Andrographis paniculata, which play a role in inhibiting SARS-CoV-2 RdRp using molecular docking. A total of 19 compounds were identified in previous literature studies, while remdesivir and favipiravir were used as the positive control. All compounds and proteins were applied to minimize and optimize energy. Furthermore, the docking method was carried out using Autodock 4.2.6 software with a specific grid box containing the active site of RdRp (ID: 6M71), and the Lamarckian Genetic Algorithm was used to determine the conformation. The best docking was screened on ADMET prediction and the binding energy was evaluated. There are 18 compounds of Andrographis paniculata including the top three, namely andrographolactone (∆G = -8.86 kcal/mol), andrographolide (∆G = -7.74 kcal/mol), and andrographidine-A (∆G = -7.68 kcal/mol), which showed the strongest binding affinity to the SARS-CoV-2 RdRp protein compared to other compounds and the positive control remdesivir (∆G = -5.73 kcal/mol) and favipiravir (∆G = -5.20 kcal/mol). Furthermore, active amino acids play a role in this interaction by forming strong hydrogen bonds, such as TYR 619, LYS 621, ASP 760, and ASP 623. Andrographolactone has the highest potential as SARS-CoV-2 RdRp inhibitor, hence, it can be used as a novel therapeutic candidate.

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